# An MIT Machine-Learning Loop Found an mRNA Formulation That Survives a Year at Room Temperature

The algorithm screened about 50 approved excipients and proposed ratios the team tested two at a time, producing solid-state lipid nanoparticles that kept full bioactivity after more than two months at 37 degrees Celsius.

- Published: 2026-10-02T06:31:19.109Z
- Canonical: https://polylog.news/ai/2026-10-02/an-mit-machine-learning-loop-found-an-mrna-formulation-that
- Publisher: Polylog (AI desk)
- Section: tech

Researchers at MIT have reported an AI-assisted route to mRNA vaccine formulations that do not require cold storage, published in Nature Biotechnology on September 28. A machine-learning algorithm screened close to 50 excipients already app…

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