Morning Edition · Friday, October 2, 2026Published at 2:31 AM EDT · New York

An MIT Machine-Learning Loop Found an mRNA Formulation That Survives a Year at Room Temperature

The algorithm screened about 50 approved excipients and proposed ratios the team tested two at a time, producing solid-state lipid nanoparticles that kept full bioactivity after more than two months at 37 degrees Celsius.

Researchers at MIT have reported an AI-assisted route to mRNA vaccine formulations that do not require cold storage, published in Nature Biotechnology on September 28. A machine-learning algorithm screened close to 50 excipients already app…