Morning Edition · Thursday, November 12, 2026Published at 1:18 AM EST · New York

AlphaGenome 2 finds 30% of causal variants on the TenK10K test, nearly double its predecessor

DeepMind's new model predicts a variant's effect one cell type at a time from a 1-megabase (about 1 million DNA base pair) window of sequence. It was trained on more than 107 million single-cell profiles and is now in private preview for commercial research.

Google DeepMind released AlphaGenome 2 on November 11. The model predicts how a DNA change affects gene regulation in a specific cell type. The first AlphaGenome made predictions at the level of whole tissues. As the AI Post channel put it,…